Abstract: Obsessive compulsive disorder (OCD) is a kind of mental disorder which is characterized by intrusive thoughts and ritual behaviors. In recent years the failure of inhibition has been widely used as the reason of obsession and compulsion. As a result, the question of whether the failure of inhibition exists on OCD patients preoccupied researchers’ attention. Unfortunately, during the past two decades, although there were plenty of research findings in this field, there were still many limitations, the first of which was the long-standing contradictory conclusions about the existence of inhibition difficult on OCDs due to all the different tasks applicable to the study of inhibition. Moreover, the cognitive neuropsychological mechanisms of inhibition haven’t been extensively studied. Based on the problems mentioned above, we explored the existence of the failure of inhibition by means of experiment and the co-occurrence of inhibition difficult on GADs was studied simultaneously. In particular, whether it has the effect of inhibiting or promoting effect in obsessive compulsive disorder is a need to solve the problems in the current research. Therefore, the international relatively new inhibition and promotion mode will be adopted to explore the inhibitory and promote effect of patients with obsessive-compulsive disorder and whether they have a common influence on patients with obsessive-compulsive disorder in this study. The study used behavioral experiment to explore this issue. 75 subjects were selected to attend the experiment, including 25 patients with obsessive-compulsive disorder, 25 patients with anxiety disorder and 25 healthy subjects. The measurement tools included DSM-IV-TR, Yale-Brown Obsessive-Compulsive Scale, Beck Anxiety Inventory and Wechsler Adult Intelligence Scale. Chinese Affective Picture System designed by Bai, Ma, Huang and Luo(2005) was chosen as experiment materials. The whole experiment was performed on a PC machine. Experimental design was single factor experiment. Among them, the independent variable is the group (the patients with obsessive-compulsive disorder, anxiety disorder and normal control group), and the average response time of the test is the dependent variable of the test. In particular, the average reaction time of the subjects was mainly included in the promotion and inhibition of the task of the time point 1 and the time point of the time point of the 2 images to stimulate the reaction time. The main results were as follows: (1) There were two potential mechanisms that might led to the failure of inhibition on OCDs named facilitation and inhibition. By means of a task that could separate the two effects, we found that the failure of inhibition was the main mechanism which led to OCD. Compared with inhibition, the effect of facilitation was negligible. (2) Inhibition of the difficulty is a unique mechanism for patients with obsessive compulsive disorder, rather than the "shared substance" in patients with anxiety disorder "

Key words: Obsessive compulsive disorder, inhibition difficulty, facilitating effect, anxiety disorder

摘要： 强迫症的发病是抑制困难还是促进效应, 或者是两者共同起作用的缘故, 是当前强迫症研究中急需解决的问题。因此, 本研究采用国际上较为新颖的抑制与促进范式, 探讨强迫症患者的抑制困难与促进效应, 并且进一步探寻了作为焦虑障碍一种的强迫症是否与其他焦虑障碍共同存在抑制与促进效应。结果发现: (1) 强迫症患者存在抑制困难与促进效应, 但是同正常个体组相比, 促进效应较为微弱, 而抑制困难作用则更为凸显; (2) 抑制困难是强迫症患者的特有的机制, 而不是与焦虑障碍患者的“共享物”。

关键词: 强迫症患者, 抑制困难, 促进效应, 焦虑障碍