This study explored the mediating influence of self-control and depression on the relation between social support and subjective well-being in 300 college students with questionnaires. The result showed: (1) self-control and depression were all mediator factors between social support and subjective well-being; (2) Depression and self-control interacted to mediate the relationship of social support and subjective well-being. The next analyses by EQS5.7b validated the results more.