Abstract To revea1 the impact of mobile phone motive and loneliness on university students’ mobile phone addiction. Using Mobile Phone Addiction Index(MPAI), UCLA Scale and Mobile Phone Addiction Motive Scale（MPUM）, 442 university students were surveyed , Analysis of muti-variance and structural equation models were adopted. The result indicated: (1) There were significant positive correlation between mobile phone addiction(four factors)and mobile phone motive, loneliness. Furthermore, there were closer correlation between them and “Escape”factor(r =0.39，p<0.01；r=0.48，p<0.01）. (2) There were significant group difference divided by different level of loneliness on mobile phone addiction(four factors)and cyber entertainment motive（Wilks’λ=0.82，p<0.001）The lonely students scored the highest scores (53.4±10.3，13.1±2.9), then the common students(42.8±6.8，13.8±3.4） and the non- loneliness group scored the lowest scores （31.9±7.5，14.6±3.4）.(3) Loneliness can positive predict mobile phone addiction（β=0.3，p<0.001）, Cyber entertainment motive had mediator effect between loneliness and mobile phone addiction(0.1) Conclusions: Loneliness palyed an important role in university students’ mobile phone addiction which can directly or indirectly predict mobile phone addiction.Therefrore the intervention of the university students’ mobile phone addiction should focus on it. Key Words mobile phone addiction, university students, loneliness, mobile phone motive