Antisaccades and Its Experimental Paradigm, Mechanisms and Influence Factors

Zhu DANG

Journal of Psychological Science ›› 2012, Vol. 35 ›› Issue (1) : 16-23.

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Journal of Psychological Science ›› 2012, Vol. 35 ›› Issue (1) : 16-23.

Antisaccades and Its Experimental Paradigm, Mechanisms and Influence Factors

  • 1,Zhu DANG2, 3
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Abstract

Antisaccades task is the main method to study the endogenous saccades. In 1978, Hallett used the antisaccades task in his study for the first time. This task needs the subjects to inhibit the saccade towards the peripheral target, and direct their gaze in the opposite direction. The antisaccades task provides an efficient method for the study of behavioral control and attention. Evidence suggests that prosaccades and antisaccades can be programmed in parallel and competition, and fronto-parietal subcortical network involved in the antisaccades performance. Antisaccades can be influenced by many factors, such as, gap effect, working memory, cognitive aging, eccentricity effect, ect.

Key words

antisaccades / prosaccades / endogenous saccades / working memory / gap effect.

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Zhu DANG. Antisaccades and Its Experimental Paradigm, Mechanisms and Influence Factors[J]. Journal of Psychological Science. 2012, 35(1): 16-23

References

陈庆荣, 谭顶良, 邓铸, 周临, 张晓丽. (2009). 眼跳的研究范式及其主要认知功能. 心理科学进展, 17, 1197-1210. 陈玉英, 隋光远, 瞿彬. (2008). 自主控制眼跳: 实验范式、神经机制和应用. 心理科学进展, 16, 154-162. 任延涛, 韩玉昌, 隋雪. (2006). 视觉搜索过程中的眼跳及其机制. 心理科学进展, 14, 340-345. 杨永胜, 丁锦红. (2008). 系列眼跳的产生及其心理学意义. 心理科学进展, 16, 240-249. Bagary,M., S.,Hutton, S. B., Symms,M.R., Barker,G. J.,Mutsatsa, S.H., Barnes, T. R., et al. (2004). Structural neural networks subserving oculomotor function in first-episode schizophrenia. Biological Psychiatry, 56, 620-627. Biscaldi, M., Fischer, B., & Stuhr, V. (1996). Human express-saccade makers are impaired at suppressing visually-evoked saccades. J Neurophysiol, 76, 199–214. Blaukopf, C. L., & DiGirolamo, G. J. (2006). Differential effects of reward and punishment on conscious and unconscious eye movements. Experimental Brain Research, 174, 786-792. Butler, K. M., & Zacks, R. T. (2006). Age deficits in the control of prepotent responses: evidence for an inhibitory decline. Psychology and Aging, 21, 638-642. Chan, F., Armstrong, I. T., & Pari, G. (2005). Deficits in saccadic eye-movement control in Parkinson’s disease. Neuropsychologia, 43, 784-796. Crawford, T. J., Bennett, D., Lekwuwa, G., Shaunak, S., & Deakin, J. F. (2002). Cognition and the inhibitory control of saccades in schizophrenia and Parkinson’s disease. Progress in Brain research, 140, 449-466. Crawford, T. J., Higham, S., Renvoize, T., Patel, J., Dale, M., Suriya, A., et al. (2005). Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer’s disease. Biological Psychiatry, 57, 1052-1060. Dafoe, J., Armstrong, I., & Munoz, D. (2007). The influence of stimulus direction and eccentricity on pro- and anti-saccades in humans. Experimental Brain Research, 179, 563-570. Dorris, M. C., & Munoz, D. P. (1995). A neural correlate for the gap effect on saccadic reaction times in monkey. Journal of Neurophysiology, 73, 2558-2562. Edelman, J. A., & Keller, E. L. (1996). Activity of visuomotor burst neurons in the superior colliculus accompanying express saccades. Journal of Neurophysiology, 76, 908-926. Eenshuistra, R. M., Ridderinkhof, K. R., & van der Molen, M. W. (2004). Age-related changes in antisaccade task performance: Inhibitory control or working memory engagement? Brain and Cognition, 56, 177-188. Ettinger, U., Antonova, E., Crawford, T. J., Mitterschiffthaler, M. T., Goswani, S., Sharma, T., et al. (2005a). Structural neural correlates of prosaccade and antisaccade eye movements in healthy humans. Neuroimage, 24, 487-494. Evdokimidis, I., Smyrnis, N., Constantinidis, T. S., Stefanis, N. C., Avramopoulos, D., Paximadis, C., Thelcritis, C., Efstratiadis, C., Kastrinakis, G., Stefanis, C. N. (2002). The antisaccade TASK in a sample of 2006 young males. I. Normal population characteristics. Experimental Brain Research, 147, 45-52 Evdokimidis, I., Tsekou, H., & Smyrnis, H. (2006). The mirror antisaccade task: direction–amplitude interaction and spatial accuracy characteristics. Experimental Brain Research, 174, 304-311 Everling, S., & Fischer, B. (1998). The antisaccade: A review of basic research and clinical studies. Neuropsychologia, 36, 885-899. Everling, S., Spantekow, A., Krappmann, P., & Flohr, H. (1998). Eventrelated potentials associated with correct and incorrect responses in a cued antisaccade task. Experimental Brain Research, 118, 27-34. Fischer, B., Biscaldi, M., & Gezeck, S. (1997). On the development of voluntary and reflexive components in human saccade generation. Brain Research, 754, 285-297. Fischer, B., & Boch, R. (1983). Saccadic eye movements after extremely short reaction times in the monkey. Brain Research, 260, 21-26. Fischer, B., & Weber, H. (1993). Express saccades and visual attention. Behavioral & Brain Sciences, 16, 553-567. Fischer, B., & Weber, H. (1997). Effects of stimulus conditions on the performance of antisaccades in man. Experimental Brain Research, 116, 191-200. Forbes, K., & Klein, R. M. (1996). The magnitude of the fixation offset effect with endogenously and exogenously controlled saccades. Journal of Cognitive Neuroscience, 8, 344-352. Funahashi, S., Chafee, M. V. & Goldman-Rakic, P. S. (1993). Prefrontal neuronal activity in rhesus monkeys performing a delayed antisaccade task. Nature, 365, 753-756. Goldring, J., & Fischer, B. (1997). Reaction times of vertical prosaccades and antisaccades in gap and overlap tasks. Experimental Brain Research, 97, 88-103. Gooding, D. C., & Tallent, K. A. (2001). The association between antisaccade task and working memory task performance in schizophrenia and bipolar disorder. Journal of Nervous and Mental Disease, 189, 8-16. Guitton, D., Buchtel, H. A. & Douglas, R. M. (1985). Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal directed saccades. Experimental Brain Research, 58, 455-472. Hallett, P. E. (1978). Primary and secondary saccades to goals defined byinstructions. Vision Research, 18, 1279-1296. Hutton, S. B., & Ettinger, U. (2006). The antisaccade task as a research tool in psychopathology: A critical review. Psychophysiology, 43, 302-313. Hutton, S. B., Huddy, V., Barnes, T. R., Robbins, T.W., Crawford, T. J., Kennard, C., et al. (2004). The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry, 56, 553-559. Kalesnykas, R. P., & Hallett, P. E. (1994). Retinal eccentricity and the latency of eye saccades. Vision Research, 94, 517-531. Klein, C., & Foerster, F. (2001). Development of prosaccade and antisaccade task performance in participants aged 6 to 26 years. Psychophysiology, 38, 179-189. Koval, M., Ford, K., & Everling, S. (2004). Effect of stimulus probability on anti-saccade error rates. Experimental Brain Research, 159, 268-272. Krappmann, P., Everling, S., & Flohr, H. (1998). Accuracy of visually and memory-guided antisaccades in man. Vision Research, 38, 2979-2985. Kristjánsson, á. (2007). Saccade landing point selection and the competition account of pro- and antisaccade generation: The involvement of visual attention – A review. Scandinavian Journal of Psychology, 48, 97-113. Kristjánsson, á., Chen, Y., & Nakayama, K. (2001). Less attention is more in the preparation of antisaccades, but not prosaccades. Nature Neuroscience, 4, 1037-1042. Kristjánsson, á., Vandenbroucke, M. W., Driver, J. (2004). When pros become cons for anti-versus prosaccades: Factors with opposite or common effects on different saccade types. Experimental Brain Research, 155, 231-244. Massen, C. (2004). Parallel programming of exogenous and endogenous components in the antisaccade task. Quarterly Journal of Experimental Psychology A, 57, 475-498. Matsuda, T., Matsuura, M., Ohkubo, T., Ohkubo, H., Matsushima, E., Inoue, K., Taira, M. & Kojima, T. (2004). Functional MRI mapping of brain activation during visually guided saccades and antisaccades: Cortical and subcortical networks. Psychiatry Research, 131, 147-155. Medendorp, W. P., Goltz, H. C., & Vilis, T. (2005). Remapping the remembered target location for anti-saccades in human posterior parietal cortex. Journal of Neurophysiology, 94, 734-740. Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167-202. Mitchell, J. P., Macrae, C. N., & Gilchrist, I. D. (2002). Working memory and the suppression of reflexive saccades. Journal of Cognitive Neuroscience, 14, 95-103. Mokler, A., & Fischer, B. (1999). The recognition and correction of involuntary prosaccades in an antisaccade task. Experimental Brain Research, 125, 511-516. Müri, R. M., Heid, O., Nirkko, A. C., Ozdoba, C., Felblinger, J., Schroth, G., et al. (1998). Functional organisation of saccades and antisaccades in the frontal lobe in humans: A study with echo planar functional magnetic resonance imaging. Journal of Neurology, Neurosurgery and Psychiatry, 65, 374-377. Munoz, D. P., & Everling, S. (2004). Look away: the anti-saccade task and the voluntary control of eye movement. Nature Reviews Neuroscience, 5, 218-228. Nieuwenhuis, S., Broerse, A., Nielen, M. M. A., & de Jong, R. (2004). A goal activation approach to the study of executive function: An application to antisaccade tasks. Brain and Cognition, 56, 198-214. O’Driscoll, G. A., Alpert, N.M., Matthysse, S. W., Levy, D. L., Rauch, S. L., & Holzman, P. S. (1995). Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proceedings of the National Academy of Sciences, USA, 92, 925-929. Olk, B., & Kingstone, A. (2003). Why are antisaccades slower than prosaccades? A novel finding using a new paradigm. Neuroreport, 14, 151-155. Olincy, A., Ross, R. G., Youngd, D. A., & Freedman, R. (1997). Age diminishes performance on an antisaccade eye movement task. Neurobiology of Aging, 18, 483-489. Peltsch, A., Hemraj, A., Garcia, A., & Munoz, D. P. (2009). Age-related trends in saccade characteristics among the elderly. Neurobiology of Aging, in press. Pierrot-Deseilligny, C., Ploner, C. J., Müri, R. M., Gaymard, B., & Rivaud-Pechoux, S. (2002). Effects of cortical lesions on saccadic eye movements in humans. Annals of the New York Academy of Science, 956, 216-229. Pratt, J., Dodd, M., & Welsh, T. (2006). Growing older does not always mean moving slower examining aging and the saccadic motor system. Journal of Motor Behavior, 38, 373-382. Richards, J. E. (2003). Cortical sources of event-related potentials in the prosaccade and antisaccade task. Psychophysiology, 40, 878-894. Reuter, B., & Kathmann, N. (2004). Using saccade tasks as a tool to analyze executive dysfunctions in schizophrenia. Acta Psychologica, 115, 255-269. Roberts, R. J., Hager, L. D., & Heron, C. (1994). Prefrontal cognitive processes: Working memory and inhibition in the antisaccade task. Journal of Experimental Psychology: General, 123, 374-393. Rommelse, N., Stigchel, S., & Sergeant, J. (2008). A review on eye movement studies in childhood and adolescent psychiatry. Brain and Cognition, 68, 391-414. Smyrnis, N., Evdokimidis, I., Stefanis, N. C., Constantinidis, T. S., Avramopoulos, D., Theleritis, C., et al. (2002). The antisaccade task in a sample of 2006 young males—II. Effects of task parameters. Experimental Brain Research, 147, 53-63. Sweeney, J. A.,Mintun, M. A., Kwee, S.,Wiseman,M. B., Brown, D. L., Rosenberg, D. R., et al. (1996). Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. Journal of Neurophysiology, 75, 454-468. Taylor, A. J., & Hutton, S. B. (2009). The effects of task instructions on pro and antisaccades performance. Experimental Brain Research, 195, 5-14. Tatler, B. W., & Hutton, S. B. (2007). Trial by trial effects in the antisaccade task. Experimental Brain Research, 179, 387-396. Unsworth, N., Schrock, J., & Engle, R. W. (2004). Working Memory Capacity and the Antisaccade Task: Individual Differences in Voluntary Saccade Control. Journal of Experimental Psychology: Learning, Memory, and Cognition, 30, 1302-1321. Weber, H., Aiple, F., Fischer, B., & Latanov, A. (1992). Dead zone forexpress saccades. Experimental Brain Research, 89, 214-222. Zhang, M., & Barash, S. (2000). Neuronal switching of sensorimotor transformations for antisaccades. Nature, 408, 971-975.

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