The content of regrets lies outside the mainstream of regret research for decades due to lack of theoretical summary. It was not until 2005 that Roese and Summerville proposed an opportunity principle to explain the rankings of people’s biggest life regrets. They first developed a 12-category framework of life domains, and then did a meta-analysis of eleven previous regret ranking studies with this framework. The results revealed that Americans’ six biggest regrets fell into the following life domains (in descending order): education, career, romance, parenting, self-improvement, and leisure. Their laboratory evidences further showed that greater perceived opportunity within twelve life domains would evoke more intense regret. On basis of these findings, Roese and Summerville (2005) developed an anti-intuitive opportunity principle, which claimed that opportunity bred regret. However Beike, Markman and Karadogan (2009) showed that feelings of regret were more likely elicited by perceptions of lost opportunity but those of future opportunity. Using the framework of life domains, we did a simple meta-analysis with two Chinese biggest regrets research, including one big-sample survey. The Chinese results showed remarkable agreement with American’s on one hand, that is, Chinese five biggest regrets centered on (in descending order) education, career, self-improvement, romance and parenting. On the other hand, there were some differences between the two countries: 1) regrets in a unique life domain of guangxi in Chinese sample ranked sixth, and 2) there were no regrets in the domains of spirituality and community for the Chinese participants. The finding suggests that besides (lost) opportunity, the importance of life domain would play a vital role in regret as well.