Starting from people's strong demand for belonging, social exclusion will hinder its realization and bring great harm to people's physical and mental health. Therefore, it is necessary to explore the influence of social exclusion and its intervention factors. Previous studies have shown that social rejection leads to social anxiety. In addition, fear of negative evaluation is an important predictor of social anxiety. And interpersonal trust is the lubricant of interpersonal relationship.So the purposes of the present study is to explore the relationship between social exclusion of college students, fear of negative evaluation, interpersonal trust and social anxiety as well as the mechanism the effect of social exclusion of college students on social anxiety of college students. A total sample of 425 college students from some universities was selected, with 150 males. The questionnaires included the Social Exclusion Questionnaire for Undergraduate(SEQU), Social Anxiety Subscale for the Self-Consciousness Scale (SASSCS), Brief Fear of Negative Evaluation Scale (BFNES), and Interpersonal Trust Scale(ITS). Data was collected and analyzed with Spss 24.0 and Amos17.0, and the bias-corrected percentile bootstrap method was used to analyze the role of interpersonal trust and fear of negative evaluation between social exclusion and social anxiety of college students.A single factor model was calculated to test the common method variance.Results showed that the study was inexistent common method variance. The results show that: (1)The structural equation model(SEM)reveals that the data fits the theoretical model well(2/df=2.61,GFI=.90,AGFI=.87,RMSEA=.06); (2) Social exclusion of college students has?a?significant direct?effect on social anxiety(β=.20，p<.01), and its confidence interval of 95% is[.06, 0.32]; Social exclusion of college students has?a?significant direct?effect on fear of negative evaluation (β=.37，p<.01), and its confidence interval of 95% is?[.24, .49]; Fear of negative evaluation has?a?significant direct on social anxiety (β=.56，p<.01), and its confidence interval of 95% is[.41, .71]; interpersonal trust has?a?significant direct?effect on social anxiety (β=-.13，p<.01), and its confidence interval of 95% is?[.03, .24]; Social exclusion of college students has a significant indirect?effect on social anxiety through fear of negative evaluation, and its confidence interval of 95% is [.12, .32]; (4) Interpersonal trust moderates the relation between social exclusion of college students and social anxiety, that is, there is a significant positive relation between social exclusion of college students and social anxiety under the low interpersonal trust level, however, there is a non significant relation between social exclusion of college students and social anxiety under the high interpersonal trust level. It is concluded that in the structural equation model of social exclusion of college students on social exclusion, fear of negative evaluation plays a partial mediating role and interpersonal trust moderates the indirect effect.These findings suggest some measures of prevention and treatment for college students’ aggression should be taken. Schools and families should set up a good core self-evaluation system in order to help them improve their social support level and eradicate aggression.These findings suggest some measures of prevention and treatment for college students`social exclusion should be taken. Schools and families should set up a good trust system in order to help them improve their interpersonal trust level and eradicate the influence of social exclusion.