Internet addiction is always a hot topic in psychology. With the rapid development of mobile Internet, mobile phone addiction behavior gradually becomes a new form of addiction. At present, college students are faced with different degrees of mobile phone addiction, which has become a worldwide problem due to its high incidence, high growth rate and susceptibility of serious adverse consequences. In some countries, the incidence of mobile phone addiction among adolescents is about 30%, It’s about 46% among college students, and it is still growing rapidly. College students' mobile phone addiction damages the daily social and psychological functions of users, which may lead to individual physical and psychological problems such as sleep disturbance, attention deficit, depression, anxiety, etc. Therefore, it is necessary to study the influencing factors of college students' mobile phone addiction. Among the factors that influence college students' mobile phone addiction, perceived stress, self-control and learning burnout are strong predictors. So the purpose of this study is to explore the relationship and the influencing mechanism between perceived stress, self-control and learning burnout on college students' mobile phone addiction. Based on previous studies and theoretical models, we proposed the following hypothesis: H1: Perceived stress may lead to college students' mobile phone addiction; H2: Self-control plays a mediating role between perceived stress and college students' mobile phone addiction; H3: Learning burnout plays a mediating role between perceived stress and college students' mobile phone addiction; H4: Perceived stress influences college students' mobile phone addiction through serial mediating effect of self-control and learning burnout. To test the hypothesis, we selected 1000 college students from two universities of Guizhou province , with 380 males and 536 females and 48 missing gender information. The range of the age is from 16 to 24 years old. The questionnaires included the Perceived Stress Scale(PSS), Self-Control Scale(SCS), Learning Burnout Scale(LBS) and Mobile Phone Addiction Scale(MPAS). We used SPSS 25.0 to analyze the data, and the Bias-Corrected Percentile Bootstrap method was used to analyze the serial mediating effect of self-control and learning burnout between perceived stress and mobile phone addiction. The results showed that: (1) Perceived stress had a significantly positive correlation with mobile phone addiction (r=.46, p<.01), and the direct effect value of perceived stress on mobile phone addiction was.29, Boot CI[.14,.44]; (2) The indirect effect value of self-control between perceived stress and mobile phone addiction was.32，Boot CI[.24, .42]; (3) The indirect effect value of learning burnout between perceived stress and mobile phone addiction was.09，Boot CI[.05, .15]; (4)The indirect effect value of serial mediating effect of self-control and learning burnout between perceived stress and mobile phone addiction was.08, Boot CI[.04,.13]. The total effect was.78, and the mediating effect accounted for 62.82% of the total effect. Based on the results above, it points out that perceived stress, self-control and learning burnout are the important influencing factors of college students' mobile phone addiction. Perceived stress affects college students' mobile phone addiction directly and indirectly through serial mediating effect of self-control and learning burnout. Therefore, These findings may contribute to a better way to solve college students’ mobile phone addiction. Moreover, it can provide us some constructive suggestions and measures to prevent and eradicate college students’ mobile phone addiction.