Sleep is one of the basic physiological needs of human beings and plays a vital role in maintaining the various functions of the human body. But in recent years, with the rapid development of the market economy and the rapid development of social processes, sleep problems are puzzling more and more people. In the economic field, low-quality sleep not only harms the physical and mental health of employees, but also affects work performance, work safety, work attitude and so on. Previous drug treatments for sleep disorders are thought to be single and have side effects, while cognitive behavioral therapy is considered an effective treatment for insomnia. This study is also based on this status quo to explore the effect of relevant psychological factors on sleep quality, and through the conclusion of the study to improve the sleep quality of employees to provide psychological level of theoretical and methodological support. Many empirical studies have found that the level of perceived stress in individuals can negatively predict sleep quality, but previous studies have less explored the intermediary mechanism of perceived stress affecting the sleep quality of employees, and it is not clear how perceived stress affects sleep quality. According to studies, there is a strong link between stress, anxiety, and sleep quality. Therefore, this study will assume that anxiety acts as a mediator between perceived stress and employee sleep quality in an enterprise, thus clarifying the internal mechanism of perceived stress affecting employee sleep quality. At the same time, although perceived stress can have an important effect on sleep quality through direct or indirect action, this effect is not fixed, and there may be certain individual differences. The study found that the higher the trait mindfulness level, the better the individual's sleep quality, so this study assumes that positive mindfulness levels play a regulatory role in negatively predicting sleep quality by perceived stress. Chinese Perceived Stress Scale, CPSS, Pittsburgh Sleep Quality Index (Pittsburgh Sleep Quality Index, PSQI), Self-Rating Anxiety Scale (SAS) and Mindfulness Awareness Scale (Mindful Attention Awareness Scale, MAAS) were used in the study. A questionnaire survey of 420 employees of small and medium-sized enterprises in Chengdu. The results show that the stress of awareness is an important factor affecting sleep quality, which is consistent with previous studies. Anxiety is an important intermediary between the stress of awareness and the quality of sleep, and the stress of awareness cannot only directly affect the sleep quality of employees in enterprises, but also play an indirect role through anxiety. This study also found that mindfulness as a personal trait regulates the mediating role of anxiety between perceived stress and sleep quality, thereby regulating the effect of perceived stress on sleep quality, that is, mindfulness levels regulate the latter half of perceived stress, anxiety, as well as sleep quality. For groups with high levels of mindfulness, although anxiety has a significant negative predictive effect on the sleep quality of enterprise employees, the slope is small, which indicates that anxiety has less effect on sleep quality for groups with high levels of mindfulness. To sum up, this study constructs and examines a regulated mediating model, explores the internal mechanism between the stress of awareness and the sleep quality of employees, and clarifies that stress of awareness predicts the sleep quality of employees through anxiety. And the mindfulness level has a regulatory effect on this mediation path, and for employees with high mindfulness levels, anxiety has less effect on their sleep quality. When the employee's mindfulness level is high, it is able to maintain uncritical awareness of internal and external stimuli, thereby reducing impulsive emotional and behavioral responses and reducing mental regurgitation, thereby improving sleep quality. The research results will have important reference value for improving the sleep quality of employees.