Currently, college students are living in an era of coexistence of multiple cultures and values, confronting with the problem brought from globalization and urbanization, and facing the pressure of growth, development and selection.The effects of life events on depression have already been identified, and there may also be some other factors that play important roles in depression formation. Thus, it is urgent to find depression formation of the effect of life events. Some influence factors turned to be important were chosen to find the mechanism of depression formation, self-esteem, attributional style and neuroticism were been selected. According to previous research and related theory, self-esteem and attributional style can be considered as diathesis, which can play a mediating role in the formulation of depression, meanwhile, neuroticism was treated as moderator in it. Basing on these conclusions. To integrate the current studies, this study proposed to find the mechanism of life events on depression. In order to identify the mechanisms causing depression, the influence factors of depression need to be of prime concern. To fulfill this target, previous conclusion of meta-analysis is regarded as the variables, Moreover, we just choose those mental-analysis journals with typical samples and high quality. By careful analysis of the relationship between various influencing factors, the accurate process of depression formation is found. During the research, the adolescent self-rating life events check list, multidimensional-multiattributional causality scale, five factor inventories revised neurotic subscales, self-esteem scale, center on epidemiologic studies depression scale was used. In total, 1100 participants from two universities in Shaanxi were measured, and 882 effective questionnaires were taken back eventually, with 47.5% males and the average age of 19.22 (SD=1.15). In addition, the method of principal component analysis was tested for SPSS to check whether there was the common method bias or not, and the results showed that there was no significant deviation. In the analysis of these data, the model was verified by means of correlation analysis, mediation test and moderation test. 　　The results showed that life events, self-esteem, neuroticism, attribution and depression were significantly correlated with each other. The final model showed that there were 3 paths which reflected the effects of life events on depression: life events had a direct effect on depression; attribution could mediate the relationship between life events and depression; life events could affect self-esteem through the mediating effect of attribution, and influenced depression indirectly. The direct effect of life events on depression was 50.3%, and the indirect effect was 49.7%. Meanwhile, neuroticism had a moderating effect between self-esteem and depression in the model. That is, the influence of life events on depression was a moderated mediating effect. 　　The innovations of the article lie in the prudent use of previous researches’ conclusions and the appropriate selection of the relevant factors of depression, and then a comparatively perfect model of depression formation is formed, which may have significant meaning and practical value for the future precise interventions of depression. More longitudinal researches are also expected in the future.