Time after work is the time to recover from work. Psychological detachment is an important process of work recovery. Release from work is beneficial to relieving the impact of work stress on workers' physical and mental health. However, as the main place of workers' spare time life, the burden it brings to workers may affect workers' psychological detachment. Many studies have found that working at home may reduce psychological detachment of workers, but few studies have examined the role of stress directly from family in the process of psychological detachment. Family stress may regulate the relationship between psychological detachment and health of workers. As a typical subject group in work stress research, preschool teachers are more likely to be observed. Because of the high proportion of females, their interaction between family stress and psychological detachment may be different . In this study, 215 preschool teachers in Jiangsu province were selected as subjects. We investigated the mechanism of family stress affecting psychological detachment. In this study, SPSS was used to analyze data. Descriptive statistics were used to calculate the mean and standard deviation of each variable. Pearson product difference correlation method was used to calculate the correlation coefficients among variables. Regression analysis was used to examine the moderating effect of family stress on the relationship between psychological detachment and life satisfaction. This study found that family stress can reduce the promoting effect of psychological relief on life satisfaction. Specifically, when the level of family stress is low, life satisfaction increases as the understanding goes. When family stress levels were high, the covariant relationship did not show up. The results suggest that family stress can affect the psychological relief process of workers. The results could extend the stress-release model and support the resource retention theory and the effort-recovery model. However, there are still some limitations in this study. First, cross-sectional design is adopted in this study. Cross-sectional study design could not determine causality. Further research may establish a causal relationship based on it. Second, the results of this study describe only one phenomenon, that is, the family environment may affect the effectiveness of one’s work recovery. However, the mechanism of this phenomenon needs to be further explored. Future research may examine more variables that reflect the mechanism, such as family-work boundary awareness.