Recent Progress on the Correlation between 5-HTTLPR and Depression

Abstract

Abstract:

Abstract: A regulatory variation in the serotonin transporter gene promoter region (5-HTTLPR) is considered to be related to depression. However, the effects of environmental factors and other genes could not be ignored. On one hand, 5-HTTLPR interacts with risk environmental factors: S-allele carriers would be at higher risk of depression or other emotion disorders when exposed to negative life events. On the other hand, other genes, such as CYP2C9 and BDNF gene, interact with 5-HTTLPR, accounting for the development of depression. In addition, gender and age may be potential confounding factors, and should be well controlled. Future work should highlight the mechanisms how 5-HTTLPR, risk environment factors and other genes interact with each other, enhancing the depression level of human and laboratory animals.

Key words: 5-HTTLPR, depression, interaction, life events

摘要：

摘要 5-HTTLPR是5-羟色胺转运蛋白基因启动子区域上的多态性位点，对其转录效率具有调节作用。5-HTTLPR基因型与抑郁存在相关，但必须把二者的关系置于一个多基因与环境交互作用的框架下考察。一方面，环境因素的作用不容忽视：S等位基因携带者暴露于负性生活事件时，表现出更多情绪问题，更易发生抑郁。另一方面，CYP2C9、BDNF等基因与5-HTTLPR有交互作用，共同影响抑郁的发生。此外，年龄、性别等因素会对研究结果造成混淆。未来研究应侧重于对机制的探讨。

关键词: 5-HTTLPR, 抑郁, 交互作用, 生活事件

张俊先陈杰李新影. 5-HTTLPR与抑郁相关性的研究动态[J]. 心理科学, 2012, 35(1): 226-232.

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